Welcome To Our Website!
Model of HoxA cluster in
undifferentiated THP1 cells
May 6th, 2009:
A new package of programs has been uploaded in the tools section. These are much more user friendly, and include readme files for each program that explain in detail how they work. Feel free to check it out!
April 21st, 2009:
We are currently working to make the programs available for download from this site more user-friendly. A new package will be available for download soon.
March 13th, 2009:
The 3C Primer program is now available in the
Tools section. Let us know if you have any trouble using the program.
February 3rd, 2009:
The lab's first paper was accepted!
ABOUT THE LABORATORY:
The current genomic challenge is to understand how proper gene
expression is orchestrated. Recent studies indicate that genomes are
organized into dynamic three-dimensional physical networks, which are
required for correct gene expression. The functional (physical)
connectivity between genes and regulatory DNA elements must be mapped
to understand how correct gene expression is obtained and ultimately
how the genome functions. In order to quantitatively measure the
intensity of individual DNA contacts within the genome, we make use of
Chromosome Conformation Capture (3C) and 3C Carbon Copy (5C)
technologies.