Welcome To Our Website!
Model of HoxA cluster in
undifferentiated THP1 cells
May 20th, 2011:
We've recently uploaded the MCMC5C program in the Tools
section of the website. Check it out!
ABOUT THE LABORATORY:
The current genomic challenge is to understand how proper gene
expression is orchestrated. Recent studies indicate that genomes are
organized into dynamic three-dimensional physical networks, which are
required for correct gene expression. The functional (physical)
connectivity between genes and regulatory DNA elements must be mapped
to understand how correct gene expression is obtained and ultimately
how the genome functions. In order to quantitatively measure the
intensity of individual DNA contacts within the genome, we make use of
Chromosome Conformation Capture (3C) and 3C Carbon Copy (5C)